Kurnool Medical College at Kurnool City in July 1956. The college was opened on 21 July 1956 by Sri T.T. Krishnamachari, the then Finance Minister of India. Fifty students were admitted to the M.B.B.S. course. Dr. C. Venkata Ramaiah was appointed as First Principal and Special Officer of Kurnool Medical College.Laboratories for subjects of the non-clinical course were established in due course
The college provides facilities for the following postgraduate degree/diploma courses. MS (Anatomy), MD (Physiology), MD (Biochemistry), MD (Pharmacology), MD (Microbiology), MD (Pathology), DCP, MD (Forensic Medicine), MD (SPM/Community Medicine), DPH, MS (ENT, DLO, MS (Ophthalmology), DO., MD (Geneal Medicine), MS (General Surgery), DGO, MD (Gynecology), MD (TBCD), MD (STD), MD (Pediatrics), DCH, MD (Anesthesia), MD (Radiology), DMRD, MS (Orthopedics), and recently the Medical Council of India, New Delhi has inspected this college for recognition and starting of some superspeciality course i.e. DM (Neurology), DM (Gastroenterology), DM (Nephrology), M.Ch (Pediatrics Surgery), M.Ch (Neuro surgery), M.Ch (Plastic surgery), M.Ch (Cardio thoracic surgery), DM (Cardiology), M.Ch (Urology) etc. in this College. During the year 2003, Acute Medical Care (AMC) unit and ICCU unit are started in the Government General Hospital, Kurnool.