Asthenia

Asthenia, or  de-sthenia (lack of strength, vigor) and has a weakening of the body, physical fatigue. By extension, it can affect the mental state, the libido and the intellect.

The fatigue is a symptom and a cause for medical consultation very common: In general medicine, 50% of patients complain of fatigue. The issue of consultation is to differentiate between a general fatigue, often a reaction to stress, chronic physical or mental (which can be closer to fatigue, but sometimes secondary to systemic disease) and real alarm signal of a specific pathophysiological process.

Etiology

Asthenic type 'general fatigue'

  • Stress Chronic;
  • depression;
  •  neurosis (chronic anxiety in particular);
  •  chronic fatigue syndrome (sequelae of mononucleosis);
  • Menopause;
  • Reactions to certain drugs.

Asthenia revealing in the context of a specific condition:

  •  Iron deficiency (anemia due to iron deficiency);
  • certain viral infections: influenza, mononucleosis, HIV (primary infection), hepatitis B and C (the only symptom of HCV), rhinitis, chronic;
  • certain bacterial infections: brucellosis, Q fever, Lyme disease, tuberculosis;
  • parasitic infections such trypanosomiasis (sleeping sickness);
  • Endocrine disorders: hypothyroidism, Addison's disease, Cushing syndrome, hypopituitarism, pituitary adenoma;
  • Genetic diseases especially the hemochromatosis gene (hyperabsorption iron);
  • cancer;
  • nutritional deficiency or poorly absorbing vitamin B9 (folic acid);
  •  myopathy;
  • myasthenia gravis;
  • Reaching the spinal cord;
  • asthenia iatrogenic: abuse of sedatives (medicines hypnotics), benzodiazepines, certain antipsychotics;
  • substance abuse: marijuana, alcohol, heroin, morphine and its derivatives;
  • Food poisoning due to consumption of mushrooms poisonous;
  • acute radiation above 2 Gy;
  • Disease in Philadelphia chromosome (1 or 2 cases per 100 000 people).

Causes of asthenia

  • Addison's disease
  • Anemia
  • Anxiety
  • Cancer
  • Chemotherapy
  • Chronic fatigue syndrome
  • Chronic pain
  • deconditioning/sedentary lifestyle
  • Dehydration and electrolyte disturbance
  • Depression and PMDD
  • Diabetes
  • Fibromyalgia
  • Heart disease
  • Hypothyroidism
  • Infections
  • Medications including amiodarone, Anastrazole, and fentanyl
  • Narcotics
  • Paraneoplastic syndrome
  • Polymyalgia Rheumatica
  • Pregnancy/postpartum
  • Pulmonary disease
  • Renal disease
  • Sleep disorders
  • Temporal arteritis

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